| Peyton Manning's Career Passing Stats Versus Each Team | ||||||||||
| Team | W | L | Att | Com | Pct | Yards | Yds/Att | Long | Td | Int | QB Rating |
| Arizona Cardinals | 1-0 | 2 | 1 | 50.0 | 5 | 2.5 | 5 | 0 | 0 | 104.7 |
| Atlanta Falcons | 3-1 | 124 | 89 | 71.7 | 1046 | 8.4 | 36 | 13 | 4 | 118.5 |
| Baltimore Ravens | 5-2 | 246 | 151 | 61.3 | 1873 | 7.6 | 57T | 13 | 6 | 97.8 |
| Buffalo Bills | 7-3 | 320 | 195 | 60.9 | 2250 | 7.0 | 50 | 13 | 9 | 83.9 |
| Carolina Panthers | 1-2 | 98 | 54 | 55.1 | 793 | 7.9 | 59 | 4 | 3 | 82.5 |
| Chicago Bears | 2-1 | 105 | 92 | 87.6 | 760 | 7.2 | 53T | 7 | 3 | 81.7 |
| Cincinnati Bengals | 5-0 | 169 | 108 | 63.9 | 1365 | 8.0 | 69 | 14 | 3 | 109.2 |
| Cleveland Browns | 4-0 | 144 | 94 | 62.0 | 999 | 6.9 | 51 | 2 | 1 | 75.5 |
| Dallas Cowboys | 2-1 | 111 | 71 | 63.9 | 818 | 7.4 | 54 | 5 | 3 | 89.8 |
| Denver Broncos | 4-2 | 165 | 108 | 65.4 | 1110 | 6.7 | 63 | 8 | 2 | 95.7 |
| Detroit Lions | 2-0 | 61 | 45 | 73.8 | 524 | 8.6 | 31T | 9 | 2 | 125.2 |
| Green Bay Packers | 1-1 | 84 | 53 | 63.1 | 687 | 8.2 | 36T | 8 | 1 | 115.5 |
| Houston Texans | 11-1 | 401 | 270 | 67.3 | 3292 | 8.2 | 80T | 29 | 5 | 111.3 |
| Jacksonville Jaguars | 10-3 | 403 | 287 | 71.2 | 3473 | 8.6 | 76T | 25 | 8 | 109.7 |
| Kansas City Chiefs | 5-1 | 209 | 131 | 62.6 | 1667 | 7.9 | 56 | 10 | 7 | 96.3 |
| Miami Dolphins | 4-7 | 378 | 230 | 60.8 | 2654 | 7.0 | 50T | 16 | 18 | 76.3 |
| Minnesota Vikings | 2-0 | 65 | 48 | 73.8 | 551 | 8.5 | 52T | 8 | 1 | 132.1 |
| New England Patriots | 5-9 | 508 | 309 | 60.8 | 3735 | 7.4 | 78T | 27 | 19 | 85.5 |
| New Orleans Saints | 3-2 | 157 | 103 | 65.6 | 1485 | 9.4 | 86T | 12 | 5 | 86.6 |
| New York Giants | 2-1 | 122 | 75 | 61.4 | 878 | 7.0 | 57T | 6 | 4 | 86.0 |
| New York Jets | 7-3 | 373 | 233 | 62.4 | 2503 | 6.7 | 41 | 13 | 11 | 81.4 |
| Oakland Raiders | 2-2 | 154 | 97 | 62.9 | 1082 | 7.0 | 50T | 9 | 6 | 87.0 |
| Philadelphia Eagles | 3-0 | 69 | 48 | 69.5 | 737 | 10.6 | 80T | 7 | 1 | 132.3 |
| Pittsburgh Steelers | 1-2 | 111 | 69 | 62.1 | 839 | 7.6 | 80T | 4 | 4 | 82.3 |
| San Diego Chargers | 3-3 | 270 | 161 | 59.6 | 1989 | 7.4 | 55 | 11 | 13 | 75.9 |
| San Francisco 49ers | 1-2 | 112 | 72 | 64.2 | 856 | 7.6 | 61T | 5 | 6 | 80.0 |
| Seattle Seahawks | 1-2 | 81 | 52 | 64.1 | 732 | 9.0 | 53 | 2 | 1 | 96.3 |
| St. Louis Rams | 1-1 | 70 | 37 | 55.5 | 386 | 5.5 | 36 | 2 | 1 | 72.6 |
| Tampa Bay Buccaneers | 2-0 | 84 | 63 | 75.0 | 639 | 7.6 | 52 | 3 | 2 | 98.2 |
| Tennessee Titans | 8-4 | 373 | 254 | 68.0 | 3079 | 8.2 | 68T | 20 | 10 | 99.9 |
| Washington Redskins | 2-1 | 104 | 69 | 66.3 | 854 | 8.2 | 51T | 8 | 3 | 105.2 |
| Peyton Manning's Career Rushing Stats Versus Each Team | ||||||||
| Team | W | L | Att | Yards | Avg. | Td | Sacked | Yards | Fumbles |
| Arizona Cardinals | 1-0 | 0 | 0 | 0.0 | 0 | 1 | -4 | 0 |
| Atlanta Falcons | 3-1 | 5 | 17 | 3.4 | 0 | 5 | 34 | 0 |
| Baltimore Ravens | 5-2 | 12 | 29 | 2.4 | 0 | 10 | 78 | 1 |
| Buffalo Bills | 7-3 | 26 | 79 | 3.0 | 2 | 9 | 66 | 0 |
| Carolina Panthers | 1-2 | 1 | 6 | 6.0 | 0 | 5 | 19 | 0 |
| Chicago Bears | 2-1 | 5 | 26 | 6.5 | 0 | 3 | 29 | 1 |
| Cincinnati Bengals | 5-0 | 11 | 21 | 1.9 | 1 | 3 | 12 | 0 |
| Cleveland Browns | 4-0 | 11 | 38 | 3.5 | 0 | 2 | 10 | 0 |
| Dallas Cowboys | 2-1 | 7 | 12 | 1.7 | 0 | 3 | 20 | 1 |
| Denver Broncos | 4-2 | 15 | 25 | 1.6 | 0 | 3 | 14 | 1 |
| Detroit Lions | 2-0 | 1 | 4 | 4.0 | 0 | 1 | 7 | 0 |
| Green Bay Packers | 1-1 | 3 | -8 | -2.7 | 0 | 4 | 27 | 0 |
| Houston Texans | 11-1 | 25 | 20 | 0.8 | 0 | 14 | 77 | 1 |
| Jacksonville Jaguars | 10-3 | 32 | 25 | 7.8 | 3 | 10 | 78 | 2 |
| Kansas City Chiefs | 5-1 | 14 | 7 | 0.5 | 1 | 9 | 79 | 2 |
| Miami Dolphins | 4-7 | 19 | 58 | 3.1 | 2 | 17 | 124 | 0 |
| Minnesota Vikings | 2-0 | 5 | 19 | 3.8 | 0 | 1 | 4 | 0 |
| New England Patriots | 5-9 | 24 | 74 | 3.1 | 3 | 22 | 137 | 4 |
| New Orleans Saints | 2-2 | 6 | 15 | 2.5 | 0 | 5 | 26 | 0 |
| New York Giants | 2-1 | 3 | -3 | -1.0 | 0 | 3 | 20 | 0 |
| New York Jets | 7-3 | 23 | 96 | 4.1 | 1 | 13 | 76 | 0 |
| Oakland Raiders | 2-2 | 7 | 25 | 3.5 | 0 | 8 | 53 | 0 |
| Philadelphia Eagles | 3-0 | 6 | 23 | 3.8 | 0 | 1 | 8 | 0 |
| Pittsburgh Steelers | 1-2 | 1 | 10 | 10.0 | 0 | 9 | 58 | 1 |
| San Diego Chargers | 3-3 | 10 | 6 | .6 | 1 | 10 | 54 | 1 |
| San Francisco 49ers | 1-2 | 1 | 0 | 0.0 | 0 | 3 | 10 | 0 |
| Seattle Seahawks | 1-2 | 1 | 0 | 0.0 | 0 | 3 | 6 | 0 |
| St. Louis Rams | 1-1 | 3 | 7 | 3.0 | 1 | 4 | 21 | 0 |
| Tampa Bay Buccaneers | 2-0 | 2 | -2 | -2.0 | 0 | 1 | 5 | 0 |
| Tennessee Titans | 8-4 | 17 | 56 | 3.3 | 0 | 10 | 62 | 2 |
| Washington Redskins | 2-1 | 3 | -1.0 | -.3 | 1 | 4 | 26 | 1 |
